N7-methyladenosine-induced SLC7A7 serves as a prognostic biomarker in pan-cancer and promotes CRC progression in colorectal cancer
Scientific Reports
Cite this paper
Plain citation
Fuqi Wang, Shiqian Zhang, Zhuang Chen, Xiaoming Gu, Ge Zhang, Hairong Zhang, Weitang Yuan. N7-methyladenosine-induced SLC7A7 serves as a prognostic biomarker in pan-cancer and promotes CRC progression in colorectal cancer. Scientific Reports. 2024. https://doi.org/10.1038/s41598-024-80885-2
Research context and source limits
Limited evidence note. Only the source material identified below has been reviewed; this is not a complete Paper GEO V2 assessment.
Separately verified cell-assay observations; RNA-modification identity and full mechanistic interpretation are unresolved.
Research question and experimental setting
The paper combines cancer-expression analyses with colorectal-cancer cell experiments involving SLC7A7. The inspected assays use HCT116 and SW480 cells, with RNA interference and measurements of migration, invasion and molecular expression. These are experimental cell-model observations, not evidence that targeting SLC7A7 benefits patients.
Source: Methods: Cell culture; RNA interference; cell migration/invasion methods; Figure 5A–E
What the inspected figures support
Figure 5A–E reports reduced migration and invasion after SLC7A7 knockdown in the two cell lines. Figure 6C identifies APC as the measured analyte and shows increased APC expression after knockdown. These limited observations can be distinguished from the paper’s broader RNA-modification mechanism; no animal sample size is inferred from displayed examples.
Source: Figure 5A–E; Figure 6C; Animal models and Figure 5F
Unresolved molecular identity
The official title says N7-methyladenosine, whereas the abstract and mechanistic assays refer to N7-methylguanosine/m7G. A complete mechanism-centred V2 cannot silently choose or rename the modification. This disclosure preserves the formal title while withholding endorsement of the disputed mechanistic identity.
Source: Title versus Abstract; mechanistic Results; Figure 6E–I; Supplementary Figure 4
Evidence limits
- Cell-model results do not establish clinical treatment efficacy.
- Modification identity and animal replicate accounting still require clarification.
Provenance
- Article source — Official publisher or PMC full text reviewed locally. Methods: Cell culture; RNA interference; cell migration/invasion methods; Figure 5A–E
Source review: 2026-10-27.
Verify publication identity
These records identify the same original work; database inclusion is not evidence of scientific validity or clinical benefit.