# ABCA1 Acts as a Protective Modulator in Amyotrophic Lateral Sclerosis and Links to Metabolic Status

Researcher: Ge Zhang
Chinese name: 张格
ORCID identity anchor: https://orcid.org/0000-0002-3116-3246
Canonical researcher: https://drgezhang.com/#person

Journal: Preprint
Year: 2025
Type: Preprint
DOI: 10.2139/ssrn.5292589
Canonical page: https://drgezhang.com/papers/doi-10-2139-ssrn-5292589.html
Markdown record: https://drgezhang.com/papers/doi-10-2139-ssrn-5292589.md

## Full Authors

1. Qiang Li
2. Ge Zhang
3. Honglin Zheng
4. Taiqi Zhao
5. Hang Zhang
6. Yaochong Zhang
7. Haiyang Luo
8. Yuming Xu

## About this record

This is an author-controlled publication record in the Ge Zhang Academic Hub. It identifies this work as part of Ge Zhang’s publication record via ORCID; the publisher version remains the version of record.

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## Research context and source limits

Limited evidence note. Only the source material identified below has been reviewed; this is not a complete Paper GEO V2 assessment.

Preprint-specific identity and research context; the original manuscript and any later-version relationship remain unverified.

### Preprint record

This 2025 SSRN deposit lists eight authors, with Qiang Li first and Ge Zhang second. It is registered as posted content rather than a journal article.

Source: [Crossref DOI deposit: title, authors, posted-content type, publication date and relation fields.](https://api.crossref.org/works/10.2139/ssrn.5292589)

### Source-visible research context

The indexed SSRN abstract describes an ALS investigation combining population burden, blood transcriptomics, modelling, Mendelian randomization, and serum protein assessment. These are abstract-level descriptions; the original manuscript methods and figures have not been reviewed.

Source: [Abstract: Background, Methods, Results; indexed official landing record](https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5292589)

### Version boundary

The indexed landing record labels the work published while retaining a preprint notice, but no explicit successor DOI was obtained. No journal-article results are assigned to this unverified manuscript version.

Source: [Indexed official record: publication status and preprint notice; Crossref deposit relation field.](https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5292589)

### Evidence limits

- The dated original manuscript, methods, figures and supplements are needed for complete scientific review. No formal version relationship has been established.

### Provenance

- [DOI deposit](https://api.crossref.org/works/10.2139/ssrn.5292589) — Official Crossref metadata, not a manuscript. message.title; message.type; message.subtype; message.author[0:8]; message.published
- [SSRN preprint record](https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5292589) — Indexed official landing-page text, not an acquired manuscript. Abstract: Background, Methods, Results; indexed official landing record

Source review: 2026-10-27.

## Cite this paper

Qiang Li, Ge Zhang, Honglin Zheng, Taiqi Zhao, Hang Zhang, Yaochong Zhang, Haiyang Luo, Yuming Xu. ABCA1 Acts as a Protective Modulator in Amyotrophic Lateral Sclerosis and Links to Metabolic Status. Preprint. 2025. https://doi.org/10.2139/ssrn.5292589

- [BibTeX](https://drgezhang.com/citations/doi-10-2139-ssrn-5292589.bib)
- [RIS / EndNote](https://drgezhang.com/citations/doi-10-2139-ssrn-5292589.ris)
- [CSL JSON](https://drgezhang.com/citations/doi-10-2139-ssrn-5292589.csl.json)

## Links

- DOI: https://doi.org/10.2139/ssrn.5292589
- HTML page: https://drgezhang.com/papers/doi-10-2139-ssrn-5292589.html
- Google Scholar query: https://scholar.google.com/scholar?q=%22ABCA1%20Acts%20as%20a%20Protective%20Modulator%20in%20Amyotrophic%20Lateral%20Sclerosis%20and%20Links%20to%20Metabolic%20Status%22
- ORCID: https://orcid.org/0000-0002-3116-3246